P-039 Pregnancy outcomes and genetic analysis of globozoospermic patients: A case series and review of the literature

Abstract Study question How should men with globozoospermia be managed in Assisted Reproductive Technologies (ART)? Summary answer IMSI (intracytoplasmic morphologically selected sperm injection), without oocyte activators (OA) allows to obtain a live birth, even when there is mutation of DPY19L2 gene. What known already Globozoospermia rare syndrome found less than 0.1% the infertile population. It characterized by presence spermatozoa round heads devoid acrosomes. Two main genes are involved transmission disease: SPATA 16 and DPY19L2. Only (ART) such as ICSI (intra-cytoplasmic injection) IMSI, or OA allow these couples pregnancies. There no births described after patients mutation. design, size, duration Four followed Department ART at Poissy Hospital Center, were studied between 2011 2022.All had total globozoospermia. Three tested for gene Patients technique use OA. Participants/materials, setting, methods The first patient homozygous obtained IMSI. second was not mutated. 2 performed, resulting biochemical pregnancy. third An performed obtaining pregnancy, attempt scheduled soon. fourth refused genetic testing management. Sperm donation achieving Main results role chance In this case series, we present management four globozoosperm Biology Andrology Center. We also two performing an OA, globozoospermic fact, according our review literature, 53 reports articles having benefited from have been reported patients. couples, 60 children born. However, until now where Limitations, reasons caution increase membrane permeability calcium fertilization rates. highest number population occurs birth mutated patient. Wider implications findings remains debated authorized some countries. Although study low rates it’s possible births. selection acrosome outline high magnification thus interesting alternative activators. Trial registration applicable